Folate network genetic variation, plasma homocysteine, and global genomic methylation content
نویسندگان
چکیده
منابع مشابه
Homocysteine, folate, methylation, and monoamine metabolism in depression.
OBJECTIVES Previous studies suggest that folate deficiency may occur in up to one third of patients with severe depression, and that treatment with the vitamin may enhance recovery of the mental state. There are, however, difficulties in interpreting serum and red cell folate assays in some patients, and it has been suggested that total plasma homocysteine is a more sensitive measure of functio...
متن کاملGenetic Variation in the Folate Receptor-α and Methylenetetrahydrofolate Reductase Genes as Determinants of Plasma Homocysteine Concentrations
2008 issn 1652-4063 isbn 978-91-7668-642-3 Anna Böttiger (née Börjel) was born in Hjulsjö, Hällefors 1977. She received a Master of Science in Chemistry at Karlstad University 2002. Her doctoral studies started in 2003 at the Department of Clinical Chemistry, Örebro University Hospital. In May 2005 she received a licentiate degree in biomedicine. Since 2007 she is working as a Clinical Biochemi...
متن کاملPlasma homocysteine is regulated by phospholipid methylation.
Mild hyperhomocysteinemia is an independent risk factor for cardiovascular disease. Homocysteine, a non-protein amino acid, is formed from S-adenosylhomocysteine and partially secreted into plasma. A potential source for homocysteine is methylation of the lipid phosphatidylethanolamine to phosphatidylcholine by phosphatidylethanolamine N-methyltransferase in the liver. We show that mice that la...
متن کاملNovel genomic loci influencing plasma homocysteine levels.
BACKGROUND AND PURPOSE Genetic factors that influence interindividual variation in levels of plasma homocysteine, a risk factor for vascular disease, are not fully understood. We performed linkage analyses to identify genomic regions that influence homocysteine levels in blacks and non-Hispanic whites. METHODS Subjects (n=2283) belonged to hypertensive sibships and included 1319 blacks (63+/-...
متن کاملUrinary excretion of folate catabolites responds to changes in folate intake more slowly than plasma folate and homocysteine concentrations and lymphocyte DNA methylation in postmenopausal women.
Folate turnover involves urinary excretion, fecal excretion, and catabolism that involves cleavage of the C9-N10 bond to yield pterins and para-aminobenzoylglutamate (pABG). Little is known about the relationship between the function of folate pools and their rates of catabolism. We report here an investigation of excretion of urinary pABG and its primary excretory form, para-acetamidobenzoylgl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.552.6